论文题目：Biosynthesis and regulatory mechanism of tanshinones and phenolic acids in Salvia miltiorrhiza
论文作者：Shuai Shao, Bingbing Lv, Mei Wang, Sijia Zeng, Shiying Wang, Zisong Yang and Pengda Ma
论文摘要： Salvia miltiorrhiza, a perennial plant of the genus Salvia in the family Lamiaceae, is one of the most important traditional Chinese medicinal herbs, renowned for its significant economic and medicinal value. Its application in China dates back to 200 BC, where it has been utilized clinically either as a monotherapy or in combination with other herbal medicines for treating cardiovascular and cerebrovascular diseases, as well as various other ailments. The bioactive constituents of S. miltiorrhiza primarily include lipophilic tanshinones and hydrophilic phenolic acids. Over the past decades, the biosynthetic pathways of tanshinones and phenolic acids have been elucidated. Coupled with the sequencing of its genome, substantial progress has been made in deciphering the biosynthesis and regulatory mechanisms of bioactive compounds in S . miltiorrhiza , including tanshinones, phenolic acids, flavonoids, and prenylated quinones. This review summarizes recent advances in the regulatory mechanisms underlying the biosynthesis of phenolic acids and tanshinones in S. miltiorrhiza, focusing on transcriptional regulation, post-translational modifications, and epigenetic regulation. These insights provide a foundation for enhancing the production of bioactive compounds through biotechnological approaches and advancing pharmacological applications.
丹参作为传统中药中的重要药材，广泛用于心脑血管疾病、肝脏损伤、肿瘤及神经系统疾病的治疗，其活性成分包括脂溶性的丹参酮类和水溶性的丹酚酸类。近年来，随着基因组测序与多组学技术的发展，研究人员在揭示其活性成分生物合成途径及调控机制方面取得了突破性进展。该综述文章深入梳理了多类关键转录因子（如MYB、bHLH、AP2/ERF、WRKY、bZIP、GRAS等）在调控丹参次生代谢产物合成中的作用，阐明了多条信号通路（如茉莉酸、脱落酸和水杨酸信号通路）如何共同调控相关基因表达。此外，文章还总结了在表观遗传调控、翻译后修饰等方面的最新成果，并对在合成生物学、丹参遗传育种等方面的应用进行了展望。该研究为丹参的分子育种和代谢工程奠定了理论基础，对推动中药现代化、提高药用植物活性成分产量具有重要意义。
原文链接：https://doi.org/10.1111/tpj.70358